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Generation of therapeutic protein variants with the human serum albumin binding capacity via site-specific fatty acid conjugation
Extension of the serum half-life is an important issue in developing new therapeutic proteins and expanding applications of existing therapeutic proteins. Conjugation of fatty acid, a natural human serum albumin ligand, to a therapeutic protein/peptide was developed as a technique to extend the seru...
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| Pubblicato in: | Sci Rep |
|---|---|
| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group UK
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5740134/ https://ncbi.nlm.nih.gov/pubmed/29269881 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-18029-y |
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