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Site-specific fatty acid-conjugation to prolong protein half-life in vivo
Therapeutic proteins are indispensable in treating numerous human diseases. However, therapeutic proteins often suffer short serum half-life. In order to extend the serum half-life, a natural albumin ligand (a fatty acid) has been conjugated to small therapeutic peptides resulting in a prolonged ser...
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| Publicado no: | J Control Release |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4437666/ https://ncbi.nlm.nih.gov/pubmed/23735573 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2013.05.023 |
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