Site-specific fatty acid-conjugation to prolong protein half-life in vivo

Therapeutic proteins are indispensable in treating numerous human diseases. However, therapeutic proteins often suffer short serum half-life. In order to extend the serum half-life, a natural albumin ligand (a fatty acid) has been conjugated to small therapeutic peptides resulting in a prolonged ser...

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Vydáno v:J Control Release
Hlavní autoři: Lim, Sung In, Mizuta, Yukina, Takasu, Akinori, Hahn, Young S., Kim, Yong Hwan, Kwon, Inchan
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4437666/
https://ncbi.nlm.nih.gov/pubmed/23735573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2013.05.023
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