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Generation of therapeutic protein variants with the human serum albumin binding capacity via site-specific fatty acid conjugation

Extension of the serum half-life is an important issue in developing new therapeutic proteins and expanding applications of existing therapeutic proteins. Conjugation of fatty acid, a natural human serum albumin ligand, to a therapeutic protein/peptide was developed as a technique to extend the seru...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Cho, Jinhwan, Lim, Sung In, Yang, Byung Seop, Hahn, Young S., Kwon, Inchan
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5740134/
https://ncbi.nlm.nih.gov/pubmed/29269881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-18029-y
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