Broadly neutralizing antiviral responses induced by a single-molecule HPV vaccine based on thermostable thioredoxin-L2 multiepitope nanoparticles

Vaccines targeting the human papillomavirus (HPV) minor capsid protein L2 are emerging as chemico-physically robust and broadly protective alternatives to the current HPV (L1-VLP) vaccines. We have previously developed a trivalent L2 vaccine prototype exploiting Pyrococcus furiosus thioredoxin (PfTr...

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Publicado en:Sci Rep
Autores principales: Spagnoli, Gloria, Pouyanfard, Somayeh, Cavazzini, Davide, Canali, Elena, Maggi, Stefano, Tommasino, Massimo, Bolchi, Angelo, Müller, Martin, Ottonello, Simone
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5740060/
https://ncbi.nlm.nih.gov/pubmed/29269879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-18177-1
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