Alisertib promotes apoptosis and autophagy in melanoma through p38 MAPK-mediated aurora a signaling

We investigated the efficacy of Alisertib (ALS), a selective Aurora kinase A (AURKA) inhibitor, in melanoma. We found that ALS exerts anti-proliferative, pro-apoptotic, and pro-autophagic effects on A375 and skmel-5 melanoma cells by inhibiting p38 MAPK signaling. SB202190, a p38 MAPK-selective inhi...

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Vydáno v:Oncotarget
Hlavní autoři: Shang, Yuan-Yuan, Yao, Ming, Zhou, Zhi-Wei, Jian-Cui, Li-Xia, Hu, Rong-Ying, Yu, Ying-Yao, Qiong-Gao, Biao-Yang, Liu, Yu-Xi, Dang, Jie, Zhou, Shu-Feng, Nan-Yu
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2017
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5739797/
https://ncbi.nlm.nih.gov/pubmed/29291012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.22328
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