Detection of somatic variants and EGFR mutations in cell-free DNA from non-small cell lung cancer patients by ultra-deep sequencing using the ion ampliseq cancer hotspot panel and droplet digital polymerase chain reaction

Highly sensitive genotyping assays can detect mutations in cell-free DNA (cfDNA) from cancer patients, reflecting the biology of each patient’s cancer. Because circulating tumor DNA comprises a small, variable fraction of DNA circulating in the blood, sensitive parallel multiplexing tests are requir...

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Udgivet i:Oncotarget
Main Authors: Sung, Jae Sook, Chong, Hyon Yong, Kwon, Nak-Jung, Kim, Hae Mi, Lee, Jong Won, Kim, Boyeon, Lee, Saet Byeol, Park, Chang Won, Choi, Jung Yoon, Chang, Won Jin, Choi, Yoon Ji, Lee, Sung Yong, Kang, Eun Joo, Park, Kyong Hwa, Kim, Yeul Hong
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2017
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5739783/
https://ncbi.nlm.nih.gov/pubmed/29290998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.22456
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