Detection of somatic variants and EGFR mutations in cell-free DNA from non-small cell lung cancer patients by ultra-deep sequencing using the ion ampliseq cancer hotspot panel and droplet digital polymerase chain reaction

Highly sensitive genotyping assays can detect mutations in cell-free DNA (cfDNA) from cancer patients, reflecting the biology of each patient’s cancer. Because circulating tumor DNA comprises a small, variable fraction of DNA circulating in the blood, sensitive parallel multiplexing tests are requir...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Sung, Jae Sook, Chong, Hyon Yong, Kwon, Nak-Jung, Kim, Hae Mi, Lee, Jong Won, Kim, Boyeon, Lee, Saet Byeol, Park, Chang Won, Choi, Jung Yoon, Chang, Won Jin, Choi, Yoon Ji, Lee, Sung Yong, Kang, Eun Joo, Park, Kyong Hwa, Kim, Yeul Hong
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5739783/
https://ncbi.nlm.nih.gov/pubmed/29290998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.22456
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