Detection of somatic variants and EGFR mutations in cell-free DNA from non-small cell lung cancer patients by ultra-deep sequencing using the ion ampliseq cancer hotspot panel and droplet digital polymerase chain reaction

Highly sensitive genotyping assays can detect mutations in cell-free DNA (cfDNA) from cancer patients, reflecting the biology of each patient’s cancer. Because circulating tumor DNA comprises a small, variable fraction of DNA circulating in the blood, sensitive parallel multiplexing tests are requir...

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Dettagli Bibliografici
Pubblicato in:Oncotarget
Autori principali: Sung, Jae Sook, Chong, Hyon Yong, Kwon, Nak-Jung, Kim, Hae Mi, Lee, Jong Won, Kim, Boyeon, Lee, Saet Byeol, Park, Chang Won, Choi, Jung Yoon, Chang, Won Jin, Choi, Yoon Ji, Lee, Sung Yong, Kang, Eun Joo, Park, Kyong Hwa, Kim, Yeul Hong
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2017
Soggetti:
Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5739783/
https://ncbi.nlm.nih.gov/pubmed/29290998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.22456
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