The effect of the JAK2 inhibitor TG101209 against T cell acute lymphoblastic leukemia (T-ALL) is mediated by inhibition of JAK-STAT signaling and activation of the crosstalk between apoptosis and autophagy signaling

Previous reports have shown that active JAK2 contributes to T cell acute lymphoblastic leukaemia (T-ALL) development and that JAK inhibitors may be a potential treatment for T-ALL. In the current study, the JAK2 inhibitor TG101209 was used to treat T-ALL cell lines and primary T-ALL cells. The effec...

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Bibliografiske detaljer
Udgivet i:Oncotarget
Main Authors: Cheng, Zhao, Yi, Yifang, Xie, Sisi, Yu, Haizhi, Peng, Hongling, Zhang, Guangsen
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2017
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5739771/
https://ncbi.nlm.nih.gov/pubmed/29290986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.22053
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