Exacerbation of diabetic cardiac hypertrophy in OVE26 mice by angiotensin II is associated with JNK/c-Jun/miR-221-mediated autophagy inhibition

Both diabetes and angiotensin II (Ang II) excess trigger cardiac remodeling and dysfunction, and diabetic cardiomyopathy. We hypothesized that cardiac hypertrophy associated with the development of diabetic cardiomyopathy is worsened by increased Ang II. Male type 1 diabetic OVE26 and wild-type mice...

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Udgivet i:Oncotarget
Main Authors: Qian, Ling-Bo, Jiang, Sai-Zhi, Tang, Xiao-Qiang, Zhang, Jian, Liang, Ya-Qin, Yu, Hai-Tao, Chen, Jing, Xu, Zheng, Liu, Rui-Ming, Keller, Bradley B., Ji, Hong-Lei, Cai, Lu
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2017
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5739764/
https://ncbi.nlm.nih.gov/pubmed/29290979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.21302
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