GPER is involved in the regulation of the estrogen-metabolizing CYP1B1 enzyme in breast cancer

The cytochrome P450 1B1 (CYP1B1) is a heme-thiolate monooxygenase involved in both estrogen biosynthesis and metabolism. For instance, CYP1B1 catalyzes the hydroxylation of E2 leading to the production of 4-hydroxyestradiol that may act as a potent carcinogenic agent. In addition, CYP1B1 is overexpr...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Cirillo, Francesca, Pellegrino, Michele, Malivindi, Rocco, Rago, Vittoria, Avino, Silvia, Muto, Luigina, Dolce, Vincenza, Vivacqua, Adele, Rigiracciolo, Damiano Cosimo, De Marco, Paola, Sebastiani, Anna, Abonante, Sergio, Nakajima, Miki, Lappano, Rosamaria, Maggiolini, Marcello
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5739760/
https://ncbi.nlm.nih.gov/pubmed/29290975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.22541
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