Baicalein suppresses the androgen receptor (AR)-mediated prostate cancer progression via inhibiting the AR N-C dimerization and AR-coactivators interaction

BACKGROUND: Androgen receptor (AR) plays a critical role in prostate cancer (PCa) development and progression. Androgen deprivation therapy with antiandrogens to reduce androgen biosynthesis or prevent androgens from binding to AR are widely used to suppress AR-mediated PCa growth. However, most of...

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Vydáno v:Oncotarget
Hlavní autoři: Xu, Defeng, Chen, Qiulu, Liu, Yalin, Wen, Xingqiao
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2017
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5739659/
https://ncbi.nlm.nih.gov/pubmed/29285272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.22319
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