Baicalein suppresses the androgen receptor (AR)-mediated prostate cancer progression via inhibiting the AR N-C dimerization and AR-coactivators interaction

BACKGROUND: Androgen receptor (AR) plays a critical role in prostate cancer (PCa) development and progression. Androgen deprivation therapy with antiandrogens to reduce androgen biosynthesis or prevent androgens from binding to AR are widely used to suppress AR-mediated PCa growth. However, most of...

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Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: Xu, Defeng, Chen, Qiulu, Liu, Yalin, Wen, Xingqiao
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2017
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5739659/
https://ncbi.nlm.nih.gov/pubmed/29285272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.22319
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