Preclinical study using androgen receptor (AR) degradation enhancer to increase radiotherapy efficacy via targeting radiation-increased AR to better suppress prostate cancer progression

BACKGROUND: While androgen deprivation therapy (ADT) and radiotherapy (RT) are currently used together to treat locally advanced prostate cancer (PCa), RT might have the adverse effect of increasing the PCa androgen receptor (AR) protein expression, which might then increase the resistance to contin...

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Detalles Bibliográficos
Publicado en:EBioMedicine
Main Authors: Chou, Fu-Ju, Chen, Yuhchyau, Chen, Dong, Niu, Yuanjie, Li, Gonghui, Keng, Peter, Yeh, Shuyuan, Chang, Chawnshang
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2019
Assuntos:
Research paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6412086/
https://ncbi.nlm.nih.gov/pubmed/30692044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2018.12.050
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