Cardiac-specific ablation of the E3 ubiquitin ligase Mdm2 leads to oxidative stress, broad mitochondrial deficiency and early death

The maintenance of normal heart function requires proper control of protein turnover. The ubiquitin-proteasome system is a principal regulator of protein degradation. Mdm2 is the main E3 ubiquitin ligase for p53 in mitotic cells thereby regulating cellular growth, DNA repair, oxidative stress and ap...

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Veröffentlicht in:PLoS One
Hauptverfasser: Hauck, Ludger, Stanley-Hasnain, Shanna, Fung, Amelia, Grothe, Daniela, Rao, Vivek, Mak, Tak W., Billia, Filio
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5739440/
https://ncbi.nlm.nih.gov/pubmed/29267372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0189861
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