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Image-based drug screen identifies HDAC inhibitors as novel Golgi disruptors synergizing with JQ1

The Golgi apparatus is increasingly recognized as a major hub for cellular signaling and is involved in numerous pathologies, including neurodegenerative diseases and cancer. The study of Golgi stress-induced signaling pathways relies on the selectivity of the available tool compounds of which curre...

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Bibliografiske detaljer
Udgivet i:Mol Biol Cell
Main Authors: Gendarme, Mathieu, Baumann, Jan, Ignashkova, Tatiana I., Lindemann, Ralph K., Reiling, Jan H.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Cell Biology 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5739293/
https://ncbi.nlm.nih.gov/pubmed/29074567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E17-03-0176
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