Isoprenoids responsible for protein prenylation modulate the biological effects of statins on pancreatic cancer cells

BACKGROUND: Statin treatment of hypercholesterolemia is accompanied also with depletion of the mevalonate intermediates, including farnesyl pyrophosphate (FPP) and geranylgeranyl pyrophosphate (GGPP) necessary for proper function of small GTPases. These include Ras proteins, prevalently mutated in p...

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Bibliografiske detaljer
Udgivet i:Lipids Health Dis
Main Authors: Gbelcová, Helena, Rimpelová, Silvie, Knejzlík, Zdeněk, Šáchová, Jana, Kolář, Michal, Strnad, Hynek, Repiská, Vanda, D’Acunto, Walter Cosimo, Ruml, Tomáš, Vítek, Libor
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2017
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5738693/
https://ncbi.nlm.nih.gov/pubmed/29262834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12944-017-0641-0
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