Isoprenoids responsible for protein prenylation modulate the biological effects of statins on pancreatic cancer cells

BACKGROUND: Statin treatment of hypercholesterolemia is accompanied also with depletion of the mevalonate intermediates, including farnesyl pyrophosphate (FPP) and geranylgeranyl pyrophosphate (GGPP) necessary for proper function of small GTPases. These include Ras proteins, prevalently mutated in p...

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Bibliografski detalji
Izdano u:Lipids Health Dis
Glavni autori: Gbelcová, Helena, Rimpelová, Silvie, Knejzlík, Zdeněk, Šáchová, Jana, Kolář, Michal, Strnad, Hynek, Repiská, Vanda, D’Acunto, Walter Cosimo, Ruml, Tomáš, Vítek, Libor
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2017
Teme:
Research
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5738693/
https://ncbi.nlm.nih.gov/pubmed/29262834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12944-017-0641-0
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