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In silico prediction of chemical mechanism of action via an improved network‐based inference method

BACKGROUND AND PURPOSE: Deciphering chemical mechanism of action (MoA) enables the development of novel therapeutics (e.g. drug repositioning) and evaluation of drug side effects. Development of novel computational methods for chemical MoA assessment under a systems pharmacology framework would acce...

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Bibliografische gegevens
Gepubliceerd in:Br J Pharmacol
Hoofdauteurs: Wu, Zengrui, Lu, Weiqiang, Wu, Dang, Luo, Anqi, Bian, Hanping, Li, Jie, Li, Weihua, Liu, Guixia, Huang, Jin, Cheng, Feixiong, Tang, Yun
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2016
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5738663/
https://ncbi.nlm.nih.gov/pubmed/27646592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13629
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