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Prediction of Drug-Target Interactions and Drug Repositioning via Network-Based Inference

Drug-target interaction (DTI) is the basis of drug discovery and design. It is time consuming and costly to determine DTI experimentally. Hence, it is necessary to develop computational methods for the prediction of potential DTI. Based on complex network theory, three supervised inference methods w...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Cheng, Feixiong, Liu, Chuang, Jiang, Jing, Lu, Weiqiang, Li, Weihua, Liu, Guixia, Zhou, Weixing, Huang, Jin, Tang, Yun
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3349722/
https://ncbi.nlm.nih.gov/pubmed/22589709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1002503
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