Pseudomonas aeruginosa LasB protease impairs innate immunity in mice and humans by targeting a lung epithelial cystic fibrosis transmembrane regulator–IL-6–antimicrobial–repair pathway

BACKGROUND: Pseudomonas aeruginosa lung infections are a huge problem in ventilator-associated pneumonia, cystic fibrosis (CF) and in chronic obstructive pulmonary disease (COPD) exacerbations. This bacterium secretes virulence factors that may subvert host innate immunity. OBJECTIVE: We evaluated t...

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Detalhes bibliográficos
Publicado no:Thorax
Main Authors: Saint-Criq, Vinciane, Villeret, Bérengère, Bastaert, Fabien, Kheir, Saadé, Hatton, Aurélie, Cazes, Aurélie, Xing, Zhou, Sermet-Gaudelus, Isabelle, Garcia-Verdugo, Ignacio, Edelman, Aleksander, Sallenave, Jean-Michel
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2018
Assuntos:
Respiratory Infection
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5738602/
https://ncbi.nlm.nih.gov/pubmed/28790180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/thoraxjnl-2017-210298
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