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Crosstalk Between Histone and DNA Methylation in Regulation of Retinal Matrix Metalloproteinase-9 in Diabetes
PURPOSE: Diabetes activates matrix metalloproteinase-9 (MMP-9), and MMP-9 via damaging retinal mitochondria, activates capillary cell apoptosis. MMP-9 promoter has binding sites for many transcription factors, and in diabetes its promoter undergoes epigenetic modifications, including histone modific...
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| Vydáno v: | Invest Ophthalmol Vis Sci |
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| Hlavní autoři: | , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
The Association for Research in Vision and Ophthalmology
2017
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5737805/ https://ncbi.nlm.nih.gov/pubmed/29261844 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.17-22706 |
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