The herpes viral transcription factor ICP4 forms a novel DNA recognition complex

The transcription factor ICP4 from herpes simplex virus has a central role in regulating the gene expression cascade which controls viral infection. Here we present the crystal structure of the functionally essential ICP4 DNA binding domain in complex with a segment from its own promoter, revealing...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Tunnicliffe, Richard B., Lockhart-Cairns, Michael P., Levy, Colin, Mould, A. Paul, Jowitt, Thomas A., Sito, Hilary, Baldock, Clair, Sandri-Goldin, Rozanne M., Golovanov, Alexander P.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Structural Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5737704/
https://ncbi.nlm.nih.gov/pubmed/28505309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx419
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