Protein phosphatase 1 and phosphatase 1 nuclear targeting subunit-dependent regulation of DNA-dependent protein kinase and non-homologous end joining

DNA-dependent protein kinase catalytic subunit (DNA-PKcs) plays a key role in mediating non-homologous end joining (NHEJ), a major repair pathway for DNA double-strand breaks (DSBs). The activation, function and dynamics of DNA-PKcs is regulated largely by its reversible phosphorylation at numerous...

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Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Zhu, Songli, Fisher, Laura A., Bessho, Tadayoshi, Peng, Aimin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2017
Schlagworte:
Genome Integrity, Repair and Replication
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5737533/
https://ncbi.nlm.nih.gov/pubmed/28985363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx686
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