Producing irreversible topoisomerase II-mediated DNA breaks by site-specific Pt(II)-methionine coordination chemistry

Human type II topoisomerase (Top2) isoforms, hTop2α and hTop2β, are targeted by some of the most successful anticancer drugs. These drugs induce Top2-mediated DNA cleavage to trigger cell-death pathways. The potency of these drugs correlates positively with their efficacy in stabilizing the enzyme-m...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Wang, Ying-Ren, Chen, Shin-Fu, Wu, Chyuan-Chuan, Liao, Yi-Wen, Lin, Te-Sheng, Liu, Ko-Ting, Chen, Yi-Song, Li, Tsai-Kun, Chien, Tun-Cheng, Chan, Nei-Li
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Structural Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5737487/
https://ncbi.nlm.nih.gov/pubmed/28977631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx742
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