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On the structural basis and design guidelines for type II topoisomerase-targeting anticancer drugs
Type II topoisomerases (Top2s) alter DNA topology via the formation of an enzyme–DNA adduct termed cleavage complex, which harbors a transient double-strand break in one DNA to allow the passage of another. Agents targeting human Top2s are clinically active anticancer drugs whose trapping of Top2-me...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3905874/ https://ncbi.nlm.nih.gov/pubmed/24038465 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt828 |
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