Cord blood transplantation recapitulates fetal ontogeny with a distinct molecular signature that supports CD4(+) T-cell reconstitution

Omission of in vivo T-cell depletion promotes rapid, thymic-independent CD4(+)-biased T-cell recovery after cord blood transplant. This enhanced T-cell reconstitution differs from that seen after stem cell transplant from other stem cell sources, but the mechanism is not known. Here, we demonstrate...

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Vydáno v:Blood Adv
Hlavní autoři: Hiwarkar, Prashant, Hubank, Mike, Qasim, Waseem, Chiesa, Robert, Gilmour, Kimberly C., Saudemont, Aurore, Amrolia, Persis J., Veys, Paul
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2017
Témata:
Transplantation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5737134/
https://ncbi.nlm.nih.gov/pubmed/29296868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2017010827
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