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An LC-MS Chemical Derivatization Method for the Measurement of Five Different One-carbon States of Cellular Tetrahydrofolate
The cofactor tetrahydrofolate (THF) is used to reduce, oxidize and transfer one-carbon (1C) units required for the synthesis of nucleotides, glycine, and methionine. Measurement of intracellular THF species is complicated by their chemical instability, signal dilution caused by variable polyglutamat...
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| Udgivet i: | Anal Bioanal Chem |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5737010/ https://ncbi.nlm.nih.gov/pubmed/28799108 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00216-017-0514-4 |
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