Comparative profiling of cortical gene expression in Alzheimer’s disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation

Alzheimer’s disease (AD) is the most common form of dementia, characterized by accumulation of amyloid β (Aβ) and neurofibrillary tangles. Oxidative stress and inflammation are considered to play an important role in the development and progression of AD. However, the extent to which these events co...

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Published in:Sci Rep
Main Authors: Castillo, Erika, Leon, Julio, Mazzei, Guianfranco, Abolhassani, Nona, Haruyama, Naoki, Saito, Takashi, Saido, Takaomi, Hokama, Masaaki, Iwaki, Toru, Ohara, Tomoyuki, Ninomiya, Toshiharu, Kiyohara, Yutaka, Sakumi, Kunihiko, LaFerla, Frank M., Nakabeppu, Yusaku
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5736730/
https://ncbi.nlm.nih.gov/pubmed/29259249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-17999-3
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