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Classification of gene signatures for their information value and functional redundancy

Gene signatures are more and more used to interpret results of omics data analyses but suffer from compositional (large overlap) and functional (correlated read-outs) redundancy. Moreover, many gene signatures rarely come out as significant in statistical tests. Based on pan-cancer data analysis, we...

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Podrobná bibliografie
Vydáno v:NPJ Syst Biol Appl
Hlavní autoři: Cantini, Laura, Calzone, Laurence, Martignetti, Loredana, Rydenfelt, Mattias, Blüthgen, Nils, Barillot, Emmanuel, Zinovyev, Andrei
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5736638/
https://ncbi.nlm.nih.gov/pubmed/29263798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41540-017-0038-8
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