Classification of gene signatures for their information value and functional redundancy

Gene signatures are more and more used to interpret results of omics data analyses but suffer from compositional (large overlap) and functional (correlated read-outs) redundancy. Moreover, many gene signatures rarely come out as significant in statistical tests. Based on pan-cancer data analysis, we...

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Publicat a:NPJ Syst Biol Appl
Autors principals: Cantini, Laura, Calzone, Laurence, Martignetti, Loredana, Rydenfelt, Mattias, Blüthgen, Nils, Barillot, Emmanuel, Zinovyev, Andrei
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5736638/
https://ncbi.nlm.nih.gov/pubmed/29263798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41540-017-0038-8
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