Inhibition of C1-Ten PTPase activity reduces insulin resistance through IRS-1 and AMPK pathways

Insulin resistance causes type 2 diabetes; therefore, increasing insulin sensitivity is a therapeutic approach against type 2 diabetes. Activating AMP-activated protein kinase (AMPK) is an effective approach for treating diabetes, and reduced insulin receptor substrate-1 (IRS-1) protein levels have...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Jeong, Heeyoon, Koh, Ara, Lee, Jiyoun, Park, Dohyun, Lee, Jung Ok, Lee, Mi Nam, Jo, Kyung-Jin, Tran, Huynh Nguyen Khanh, Kim, Eui, Min, Byung-Sun, Kim, Hyeon Soo, Berggren, Per-Olof, Ryu, Sung Ho
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5736594/
https://ncbi.nlm.nih.gov/pubmed/29259227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-18081-8
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