Agonistic aptamer to the insulin receptor leads to biased signaling and functional selectivity through allosteric modulation

Due to their high affinity and specificity, aptamers have been widely used as effective inhibitors in clinical applications. However, the ability to activate protein function through aptamer-protein interaction has not been well-elucidated. To investigate their potential as target-specific agonists,...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Yunn, Na-Oh, Koh, Ara, Han, Seungmin, Lim, Jong Hun, Park, Sehoon, Lee, Jiyoun, Kim, Eui, Jang, Sung Key, Berggren, Per-Olof, Ryu, Sung Ho
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Chemical Biology and Nucleic Acid Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4652772/
https://ncbi.nlm.nih.gov/pubmed/26245346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv767
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