Ubiquitin-Specific Protease 14 Negatively Regulates Toll-Like Receptor 4-Mediated Signaling and Autophagy Induction by Inhibiting Ubiquitination of TAK1-Binding Protein 2 and Beclin 1

Ubiquitin-specific protease 14 (USP14), one of three proteasome-associated deubiquitinating enzymes, has multifunctional roles in cellular context. Here, we report a novel molecular mechanism and function of USP14 in regulating autophagy induction and nuclear factor-kappa B (NF-κB) activation induce...

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Detalles Bibliográficos
Publicado en:Front Immunol
Main Authors: Min, Yoon, Lee, Sena, Kim, Mi-Jeong, Chun, Eunyoung, Lee, Ki-Young
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2017
Assuntos:
Immunology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5736539/
https://ncbi.nlm.nih.gov/pubmed/29326710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01827
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