mTORC1-Mediated Inhibition of 4EBP1 is Essential for Hedgehog Signaling-Driven Translation and Medulloblastoma

Mechanistic target of rapamycin (MTOR) cooperates with Hedgehog (HH) signaling, but the underlying mechanisms are incompletely understood. Here, we provide genetic, biochemical, and pharmacologic evidence that MTOR complex 1 (mTORC1)-dependent translation is a prerequisite for HH signaling. The gene...

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Опубликовано в: :Dev Cell
Главные авторы: Wu, Chang-Chih, Hou, Shirui, Orr, Brent A., Kuo, Bryan R., Youn, Yong Ha, Ong, Taren, Roth, Fanny, Eberhart, Charles G., Robinson, Giles W., Solecki, David J., Taketo, Makoto M., Gilbertson, Richard J., Roussel, Martine F., Han, Young-Goo
Формат: Artigo
Язык:Inglês
Опубликовано: 2017
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5736446/
https://ncbi.nlm.nih.gov/pubmed/29103956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2017.10.011
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