mTORC1-Mediated Inhibition of 4EBP1 is Essential for Hedgehog Signaling-Driven Translation and Medulloblastoma

Mechanistic target of rapamycin (MTOR) cooperates with Hedgehog (HH) signaling, but the underlying mechanisms are incompletely understood. Here, we provide genetic, biochemical, and pharmacologic evidence that MTOR complex 1 (mTORC1)-dependent translation is a prerequisite for HH signaling. The gene...

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Detalhes bibliográficos
Publicado no:Dev Cell
Main Authors: Wu, Chang-Chih, Hou, Shirui, Orr, Brent A., Kuo, Bryan R., Youn, Yong Ha, Ong, Taren, Roth, Fanny, Eberhart, Charles G., Robinson, Giles W., Solecki, David J., Taketo, Makoto M., Gilbertson, Richard J., Roussel, Martine F., Han, Young-Goo
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5736446/
https://ncbi.nlm.nih.gov/pubmed/29103956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2017.10.011
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