mTORC1-Mediated Inhibition of 4EBP1 is Essential for Hedgehog Signaling-Driven Translation and Medulloblastoma

Mechanistic target of rapamycin (MTOR) cooperates with Hedgehog (HH) signaling, but the underlying mechanisms are incompletely understood. Here, we provide genetic, biochemical, and pharmacologic evidence that MTOR complex 1 (mTORC1)-dependent translation is a prerequisite for HH signaling. The gene...

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Détails bibliographiques
Publié dans:Dev Cell
Auteurs principaux: Wu, Chang-Chih, Hou, Shirui, Orr, Brent A., Kuo, Bryan R., Youn, Yong Ha, Ong, Taren, Roth, Fanny, Eberhart, Charles G., Robinson, Giles W., Solecki, David J., Taketo, Makoto M., Gilbertson, Richard J., Roussel, Martine F., Han, Young-Goo
Format: Artigo
Langue:Inglês
Publié: 2017
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5736446/
https://ncbi.nlm.nih.gov/pubmed/29103956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2017.10.011
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