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mTORC1-Mediated Inhibition of 4EBP1 is Essential for Hedgehog Signaling-Driven Translation and Medulloblastoma
Mechanistic target of rapamycin (MTOR) cooperates with Hedgehog (HH) signaling, but the underlying mechanisms are incompletely understood. Here, we provide genetic, biochemical, and pharmacologic evidence that MTOR complex 1 (mTORC1)-dependent translation is a prerequisite for HH signaling. The gene...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Dev Cell |
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| Κύριοι συγγραφείς: | , , , , , , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2017
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5736446/ https://ncbi.nlm.nih.gov/pubmed/29103956 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2017.10.011 |
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