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Endoplasmic Reticulum Stress and Store-Operated Calcium Entry Contribute to Usnic Acid-Induced Toxicity in Hepatic Cells

The use of usnic acid as a weight loss agent is a safety concern due to reports of acute liver failure in humans. Previously we demonstrated that usnic acid induces apoptosis and cytotoxicity in hepatic HepG2 cells. We also demonstrated that usnic acid induces autophagy as a survival mechanism again...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Toxicol Sci
Prif Awduron: Chen, Si, Zhang, Zhuhong, Wu, Yuanfeng, Shi, Qiang, Yan, Hua, Mei, Nan, Tolleson, William H., Guo, Lei
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2015
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5736313/
https://ncbi.nlm.nih.gov/pubmed/25870318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfv075
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