Reticulon 4 Is Necessary for Endoplasmic Reticulum Tubulation, STIM1-Orai1 Coupling, and Store-operated Calcium Entry

Despite recent advances in understanding store-operated calcium entry (SOCE) regulation, the fundamental question of how ER morphology affects this process remains unanswered. Here we show that the loss of RTN4, is sufficient to alter ER morphology and severely compromise SOCE. Mechanistically, we s...

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Detaylı Bibliyografya
Asıl Yazarlar: Jozsef, Levente, Tashiro, Keitaro, Kuo, Andrew, Park, Eon Joo, Skoura, Athanasia, Albinsson, Sebastian, Rivera-Molina, Felix, Harrison, Kenneth D., Iwakiri, Yasuko, Toomre, Derek, Sessa, William C.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2014
Konular:
Signal Transduction
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3969502/
https://ncbi.nlm.nih.gov/pubmed/24558039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.548602
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