Reticulon 4 Is Necessary for Endoplasmic Reticulum Tubulation, STIM1-Orai1 Coupling, and Store-operated Calcium Entry

Despite recent advances in understanding store-operated calcium entry (SOCE) regulation, the fundamental question of how ER morphology affects this process remains unanswered. Here we show that the loss of RTN4, is sufficient to alter ER morphology and severely compromise SOCE. Mechanistically, we s...

Full description

Saved in:
Bibliographic Details
Main Authors: Jozsef, Levente, Tashiro, Keitaro, Kuo, Andrew, Park, Eon Joo, Skoura, Athanasia, Albinsson, Sebastian, Rivera-Molina, Felix, Harrison, Kenneth D., Iwakiri, Yasuko, Toomre, Derek, Sessa, William C.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2014
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3969502/
https://ncbi.nlm.nih.gov/pubmed/24558039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.548602
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items