Reticulon 4 Is Necessary for Endoplasmic Reticulum Tubulation, STIM1-Orai1 Coupling, and Store-operated Calcium Entry

Despite recent advances in understanding store-operated calcium entry (SOCE) regulation, the fundamental question of how ER morphology affects this process remains unanswered. Here we show that the loss of RTN4, is sufficient to alter ER morphology and severely compromise SOCE. Mechanistically, we s...

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Detalhes bibliográficos
Main Authors: Jozsef, Levente, Tashiro, Keitaro, Kuo, Andrew, Park, Eon Joo, Skoura, Athanasia, Albinsson, Sebastian, Rivera-Molina, Felix, Harrison, Kenneth D., Iwakiri, Yasuko, Toomre, Derek, Sessa, William C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3969502/
https://ncbi.nlm.nih.gov/pubmed/24558039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.548602
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