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Aptamer-Mediated Selective Delivery of a Cytotoxic Cationic NHC-Au(I) Complex to Cancer Cells

A novel cationic NHC-Au(I) complex was synthesized and studied for its antitumor activity. For all the cell lines tested, cationic NHC-Au(I) complex 2 shows much higher cytotoxicity than its neutral analogue 1. To achieve selective cancer cell targeting, complex 2 was covalently conjugated to aptame...

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Bibliografske podrobnosti
izdano v:Dalton Trans
Main Authors: Niu, Weijia, Teng, I-Ting, Chen, Xigao, Tan, Weihong, Veige, Adam S.
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5736135/
https://ncbi.nlm.nih.gov/pubmed/29192701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7dt02616a
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