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Encoding optical control in LCK kinase to quantitatively investigate its activity in live cells
LCK is a tyrosine kinase essential for initiating T-cell antigen receptor (TCR) signaling. A complete understanding of LCK function is constrained by a paucity of methods to quantitatively study its function within live cells. To address this limitation, we generated LCK*, in which a key active site...
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| Publicado en: | Nat Struct Mol Biol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2017
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5736103/ https://ncbi.nlm.nih.gov/pubmed/29083415 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3492 |
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