PAK6 Phosphorylates 14-3-3γ to Regulate Steady State Phosphorylation of LRRK2

Mutations in Leucine-rich repeat kinase 2 (LRRK2) are associated with Parkinson's disease (PD) and, as such, LRRK2 is considered a promising therapeutic target for age-related neurodegeneration. Although the cellular functions of LRRK2 in health and disease are incompletely understood, robust e...

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Detalhes bibliográficos
Publicado no:Front Mol Neurosci
Main Authors: Civiero, Laura, Cogo, Susanna, Kiekens, Anneleen, Morganti, Claudia, Tessari, Isabella, Lobbestael, Evy, Baekelandt, Veerle, Taymans, Jean-Marc, Chartier-Harlin, Marie-Christine, Franchin, Cinzia, Arrigoni, Giorgio, Lewis, Patrick A., Piccoli, Giovanni, Bubacco, Luigi, Cookson, Mark R., Pinton, Paolo, Greggio, Elisa
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5735978/
https://ncbi.nlm.nih.gov/pubmed/29311810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2017.00417
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