A novel medium size lactam ring analoges as antibacterial agents: Synthesis, biological evaluation and molecular docking studies

A novel series of medium size (S)-3-alkyl-3,4,6,7-tetrahydro-1H-benzo[e][1,4]diazonine-2,5-dione (6a-f) analogues were synthesized from (E)-3-(2-nitrophenyl)acrylicacid (2) reacting with various amino acid esters using Di-isopropyl Carbodiimide as a coupling agent. The final cyclization is carried o...

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Udgivet i:EXCLI J
Main Authors: Harita, Putcha A. N. V., Kumar, Putcha Seshi, Reddy Guduru, Shiva Krishna, Ravula, Parameshwar, Narendra Sharath Chandra, J N
Format: Artigo
Sprog:Inglês
Udgivet: Leibniz Research Centre for Working Environment and Human Factors 2017
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5735333/
https://ncbi.nlm.nih.gov/pubmed/29285005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.17179/excli2017-193
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