Function Control of Anti-microRNA Oligonucleotides Using Interstrand Cross-Linked Duplexes

MicroRNA (miRNA)-guided argonaute (Ago) controls gene expression upon binding to the 3′ UTR of mRNA. The miRNA function can be competitively inhibited by single-stranded anti-miRNA oligonucleotides (AMOs). In this study, we constructed a novel type of AMO flanked by interstrand cross-linked 2′-O-met...

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Publicado en:Mol Ther Nucleic Acids
Main Authors: Mie, Yasuhiro, Hirano, Yu, Kowata, Keiko, Nakamura, Akiyoshi, Yasunaga, Mayu, Nakajima, Yoshihiro, Komatsu, Yasuo
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Gene & Cell Therapy 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5734696/
https://ncbi.nlm.nih.gov/pubmed/29499957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2017.11.003
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