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Crystal structure of the Entamoeba histolytica RNA lariat debranching enzyme EhDbr1 reveals a catalytic Zn(2+)/Mn(2+) heterobinucleation
The RNA lariat debranching enzyme Dbr1 is a metallophosphoesterase that cleaves 2′-5′ phosphodiester bonds within intronic lariats. Previous reports have indicated that Dbr1 enzymatic activity is supported by diverse metal ions including Ni(2+), Mn(2+), Mg(2+), Fe(2+) and Zn(2+). While in initial st...
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| 出版年: | FEBS Lett |
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| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2017
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5733776/ https://ncbi.nlm.nih.gov/pubmed/28504306 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1873-3468.12677 |
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