Mechanism underlying the suppressor activity of retinoic acid on IL4-induced IgE synthesis and its physiological implication

The present study extends an earlier report that retinoic acid (RA) down-regulates IgE Ab synthesis in vitro. Here, we show the suppressive activity of RA on IgE production in vivo and its underlying mechanisms. We found that RA down-regulated IgE class switching recombination (CSR) mainly through R...

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Detalhes bibliográficos
Publicado no:Cell Immunol
Main Authors: Seo, Goo-Young, Lee, Jeong-Min, Jang, Young-Saeng, Kang, Seung Goo, Yoon, Sung-il, Ko, Hyun-Jeong, Lee, Geun-Shik, Park, Seok-Rae, Nagler, Cathryn R., Kim, Pyeung-Hyeun
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5733712/
https://ncbi.nlm.nih.gov/pubmed/29042055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellimm.2017.10.001
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