The phosphatidic acid–binding, polybasic domain is responsible for the differences in the phosphoregulation of lipins 1 and 3

Lipins 1, 2, and 3 are Mg(2+)-dependent phosphatidic acid phosphatases and catalyze the penultimate step of triacylglycerol synthesis. We have previously investigated the biochemistry of lipins 1 and 2 and shown that di-anionic phosphatidic acid (PA) augments their activity and lipid binding and tha...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Boroda, Salome, Takkellapati, Sankeerth, Lawrence, Robert T., Entwisle, Samuel W., Pearson, Jennifer M., Granade, Mitchell E., Mullins, Garrett R., Eaton, James M., Villén, Judit, Harris, Thurl E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2017
Soggetti:
Enzymology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5733587/
https://ncbi.nlm.nih.gov/pubmed/28982975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.786574
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