Lipin 2 Binds Phosphatidic Acid by the Electrostatic Hydrogen Bond Switch Mechanism Independent of Phosphorylation

Lipin 2 is a phosphatidic acid phosphatase (PAP) responsible for the penultimate step of triglyceride synthesis and dephosphorylation of phosphatidic acid (PA) to generate diacylglycerol. The lipin family of PA phosphatases is composed of lipins 1–3, which are members of the conserved haloacid dehal...

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Detalhes bibliográficos
Main Authors: Eaton, James M., Takkellapati, Sankeerth, Lawrence, Robert T., McQueeney, Kelley E., Boroda, Salome, Mullins, Garrett R., Sherwood, Samantha G., Finck, Brian N., Villén, Judit, Harris, Thurl E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4140300/
https://ncbi.nlm.nih.gov/pubmed/24811178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.547604
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