Evidence for a conserved inhibitory binding mode between the membrane fusion assembly factors Munc18 and syntaxin in animals

The membrane fusion necessary for vesicle trafficking is driven by the assembly of heterologous SNARE proteins orchestrated by the binding of Sec1/Munc18 (SM) proteins to specific syntaxin SNARE proteins. However, the precise mode of interaction between SM proteins and SNAREs is debated, as contrast...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Morey, Czuee, Kienle, C. Nickias, Klöpper, Tobias H., Burkhardt, Pawel, Fasshauer, Dirk
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2017
Subjects:
Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5733584/
https://ncbi.nlm.nih.gov/pubmed/29046354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.811182
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